fatty acid oxidation
2016-12-17 14:10:19 0 举报脂肪酸氧化（Fatty Acid Oxidation，简称FAO）是生物体内一种重要的能量代谢过程。在这个过程中，长链脂肪酸（如棕榈酸、硬脂酸等）在细胞线粒体中被逐步分解为较短的脂肪酸，同时释放出大量的能量。这个过程需要一系列酶的参与，包括脂肪酸转运蛋白、脂酰CoA合成酶、β-氧化酶等。脂肪酸氧化是动物和人体获取能量的主要途径之一，对于维持生命活动具有重要意义。此外，脂肪酸氧化还与许多生理过程密切相关，如脂肪组织发育、胰岛素敏感性、炎症反应等。因此，研究脂肪酸氧化对于理解生物体的代谢调控和疾病发生机制具有重要意义。
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Acetoacetyl-CoA
Triacylglycerol
L-β-Hydroxyacyl-CoA
Fatty acylcarnitine
Glycerol 3-phosphate
Acyl-CoA
CoA-SH
Acetone
NAD
NADP
Hydration
β-Hydoxyacyl-CoAdehydrogenase
ATP
Thiolyticcleavage
NADH
ADP
FAD
Acetyl-CoA
Methylmalonyl-CoAepimerase
Fatty acyl-CoA
Glycerol kinase
Methylmalonyl-CoAmutase(with VB12)
Fatty acyl-aldenylate-Enzyme
Propionyl-CoA
Acyl-CoAdehydrogenase
Succinyl-CoA
Dehydrogenation
β-Ketoacyl-CoA
Fatty acyl-CoAsynthetase
Odd-number
Acyl-CoAacetyltransferase(thiolase)
Acylcarnitine
2Pi
PPi
NADPH
H2O
Thiolase
Succinate
HMG-CoAlyase
trans-Δ2-acyl-CoA
AMP
HCO3-
CO2
β-Ketoacyl-CoAtransferase
trans-Δ3-acyl-CoA
FADH2
2×
Carnitineacyltransferase I(outer membrane)
Propionyl-CoAcarboxylase(with biotin)
HMG-CoA
trans-△2-Enoyl-CoA
Fatty acid
Carnitineacyltransferase II(inner face)
HMG-CoAsynthase
D-Methylmalonyl-CoA
Glycerol
Malonyl-CoA
D-β-Hydroxybutyrate
L-Methylmalonyl-CoA
Unsaturated
acyl carnitine/carnitine transporter (inner membrane)
Dihydroxyacetonephosphate
Acetoacetate
Glycerol 3-phosphatedehydrogenase
Fatty acyl-CoAsynthetase(fatty acidthiokinase)
Enol-CoAhydratase
Inorganic pyrophosphatase
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