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b cell

2023-10-31 21:30:43   5  举报

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b cell

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development<br>

negative selection<br>

rearrangement of heavy chain and light chain<br>

coupled with gene rearrangement<br>

enzymes<br>

Rag-1,Rag-2<br>

Tdt<br>

regulation<br>

allelic<br>

isotype exclusion<br>

surface markers<br>

BCR complex<br>

BCR(mlg)<br>

lgα/lgβ(CD79a/CD79b)<br>

Co-receptors<br>

CD19/CD21/CD81complex<br>

CD21<br>

抗原非共价与C3d结合，与CD21结合<br>

BCR与共受体复合物交联，放大BCR接受信号<br>

降低活化阈值，增加B细胞敏感性<br>

II型补体受体<br>

EB病毒受体

感染B细胞，导致B细胞的持续增值和转化<br>

体外建立B淋巴母细胞长期保存B 细胞克隆<br>

CD81<br>

单抗可抑制淋巴细胞增殖<br>

Co-stimulatory  molecules<br>

CD40<br>

B细胞活化的第二信号<br>

对B细胞分化和抗体产生以及类别转换有重要作用<br>

与CD40L<br>

与CD40L结合可促进APC上调B7促进T细胞活化<br>

CD80,CD86<br>

ICAM-1,LFA-1<br>

分支主题

phases and types of humoral immune respone

B2 cells (TD-Ag)<br>

requirement for Th cell help<br>

mainly lgG<br>

cell -mediated immunity,humoral immunity<br>

memory T and memory B<br>

B1 cells (TI-Ag)<br>

independent of Th cell help<br>

mainly lgM<br>

no cell-madiated,no memory<br>

子主题

phases and types of humoral immune respone

phases<br>

antigen recognition phase<br>

B cells activated by Ag(first signal)<br>

BCR complex<br>

coreceptors(CD21/CD19/CD81)<br>

Th cell-mediated activation and differentiation of B cells<br>

further activation<br>

Th cells→CD40L second signal<br>

B cells→CD40<br>

cytokines(IL-2,IFN-γ,IL-4,IL-5,IL-6,IL-13,etc.).

formation of germinal center<br>

affinity maturation<br>

heavy chain class switching<br>

proliferation and differentiation<br>

effector phase<br>

types<br>

B2→TD-Ag<br>

B1→TI-Ag

functions <br>

子主题

rearrangement of heavy chain and light chain<br>

couple with gene rearrangement<br>

enzymes for rearrangement-- Rag-1,Rag-2 and Tdt<br>

子主题

<br>

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The contexts of Progress A and B switching

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The contexts of Progress A and B switching

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