b cell
2023-10-31 21:30:43 5 举报AI智能生成
b cell
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development<br>
negative selection<br>
rearrangement of heavy chain and light chain<br>
coupled with gene rearrangement<br>
enzymes<br>
Rag-1,Rag-2<br>
Tdt<br>
regulation<br>
allelic<br>
isotype exclusion<br>
surface markers<br>
BCR complex<br>
BCR(mlg)<br>
lgα/lgβ(CD79a/CD79b)<br>
Co-receptors<br>
CD19/CD21/CD81complex<br>
CD21<br>
抗原非共价与C3d结合，与CD21结合<br>
BCR与共受体复合物交联，放大BCR接受信号<br>
降低活化阈值，增加B细胞敏感性<br>
II型补体受体<br>
EB病毒受体
感染B细胞，导致B细胞的持续增值和转化<br>
体外建立B淋巴母细胞 长期保存B 细胞克隆<br>
CD81<br>
单抗可抑制淋巴细胞增殖<br>
Co-stimulatory molecules<br>
CD40<br>
B细胞活化的第二信号<br>
对B细胞分化和抗体产生以及类别转换有重要作用<br>
与CD40L<br>
与CD40L结合 可促进APC上调B7促进T细胞活化<br>
CD80,CD86<br>
ICAM-1,LFA-1<br>
分支主题
phases and types of humoral immune respone
B2 cells (TD-Ag)<br>
requirement for Th cell help<br>
mainly lgG<br>
cell -mediated immunity,humoral immunity<br>
memory T and memory B<br>
B1 cells (TI-Ag)<br>
independent of Th cell help<br>
mainly lgM<br>
no cell-madiated,no memory<br>
子主题
phases and types of humoral immune respone
phases<br>
antigen recognition phase<br>
B cells activated by Ag(first signal)<br>
BCR complex<br>
coreceptors(CD21/CD19/CD81)<br>
Th cell-mediated activation and differentiation of B cells<br>
further activation<br>
Th cells→CD40L second signal<br>
B cells→CD40<br>
cytokines(IL-2,IFN-γ,IL-4,IL-5,IL-6,IL-13,etc.).
formation of germinal center<br>
affinity maturation<br>
heavy chain class switching<br>
proliferation and differentiation<br>
effector phase<br>
types<br>
B2→TD-Ag<br>
B1→TI-Ag
functions <br>
子主题
rearrangement of heavy chain and light chain<br>
couple with gene rearrangement<br>
enzymes for rearrangement-- Rag-1,Rag-2 and Tdt<br>
子主题
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