MRI and ultrasound showed knee joint effusion and synovial thickening
HSPSTAT3 mutation
knee joint swelling and tenderness with limited motion
4 years 7 months
HSPAllergic vasculitisDiarrheaSTAT3 mutation(GOF)
occasional joint pain
recurrent purpura，lower extremity swelling and diarrhea withmultiple viral and bacterial respiratory tract infections
arthritis resolved
purpura recurred 3 times
4 years 8 months
5 years
Ruxolitibib 5mg bid
8 months
Tofacitinib 5mg bid
recurrent episodes of knee arthritis
Arthritis ADMIO
5 years 5 months
lower extremity purpura with ankle swelling for 3 days，chronic diarrhea
Tocilizumab 160mg iv
Symptoms
Diagnosis
1 year 5 months
Adalimumab 20mg/2w
Treatment
ADMIO
Signs
swelling and tenderness of ankle，knee and hip joints with significant limitation of walking
HSP？
Examination
knee joint swelling and pain for 2 months
WES revealed STAT3 gene mutation
bilateral lower extremity purpura，edema with livedo reticularis of the feet
1 year 1 month
6 years
Intravenous methylprednisolone 1-2mg/kg and oral prednisone
purpura and edema
