miR-
2016-09-08 01:27:14 0 举报仅支持查看
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miR29
miR29
模版推荐
作者其他创作
大纲/内容
Tet1
mir29 0.99
miR-124-3p.1 0.97
Tet2
mir29 0.99
let-7-5p/98-5p 0.96
let-7d--tet2-0.96
miR-125a-5p 0.91
Tet3
mir29 0.99
let-7-5p/98-5p 0.99
let-7d--tet3-0.99
在小鼠哮喘模型中，抑制TH2反应中的IL-13（JACI）
miR-124-3p.1 0.99
miR-125a-5P 0.81
miR-29
子主题
文献
IL-6负调节TGF-β和miR-29
Zhang, Y., et al. (2016). "Deletion of interleukin-6 alleviated interstitial fibrosis in streptozotocin-induced diabetic cardiomyopathy of mice through affecting TGFbeta1 and miR-29 pathways." Sci Rep 6: 23010.
miR-29 inhibitor (AMO29)
<div>miR-29a F: 5′ -CCGTAGCACCATCTGAAATC-3′</div><div>miR-29a R: 5′ -GTATCCAGTGCGTGTCGTG-3′</div><div>U6 F: 5′ - GCTTCGGCAGCACATATACTAAAAT -3′</div><div>U6 R: 5′ - CGCTTCACGAATTTGCGTGTCAT -3′</div>
miR-29 family (miR-29a, miR-29b and miR-29c) can directly repress Tet1 expression.
Cui, Y., et al. (2016). "miR-29 regulates Tet1 expression and contributes to early differentiation of mouse ESCs." Oncotarget.
Erratum Negative feedback of miR-29 family TET1 involves in hepatocellular cancer."
Lin, L. L., et al. (2015). "Erratum to: Negative feedback of miR-29 family TET1 involves in hepatocellular cancer." Med Oncol 32(3): 39.
Lin, L. L., et al. (2014). "Negative feedback of miR-29 family TET1 involves in hepatocellular cancer." Med Oncol 31(12): 291.
miR-29 family, target gene IFN-gamma
Yi, Z. J., et al. (2013). "[Expression and bioinformatic analysis of miR-29 family, target gene IFN-gamma in CD4(+) T cells from subjects with latent tuberculosis infection]." Zhonghua Yu Fang Yi Xue Za Zhi 47(7): 632-636.
子主题
Yang, T., et al. (2013). "miR-29 mediates TGFbeta1-induced extracellular matrix synthesis through activation of PI3K-AKT pathway in human lung fibroblasts." J Cell Biochem 114(6): 1336-1342.
<span style="color: rgb(43, 43, 43); font-family: Simsun; font-size: 14px; line-height: 25.2px;">GATA3能激活microRNA-29b</span>
<b style="color: rgb(43, 43, 43); font-family: Arial, Helvetica, sans-serif; font-size: 12px; line-height: 21.6px; background-color: rgb(240, 240, 240);">GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression</b>
文章思路参考
mir155-RA
Elmesmari, A., et al. (2016). "MicroRNA-155 regulates monocyte chemokine and chemokine receptor expression in Rheumatoid Arthritis." Rheumatology (Oxford).
在con/RA/RA SF的PBMC-CD14+中用PCR发现miR155在炎症中上调
在RA/RA SF中，探讨miR155与风湿标志物ACPA、多种症状评分的相关性（不一定有统计学差异，but also a data）
<span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; line-height: 19.994px;">in vitro： RA的PB CD14+的单核细胞体外过表达miR-155 in </span><span class="highlight" style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; line-height: 19.994px;">RA</span><span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; line-height: 19.994px;"> monocytes stimulated the production of CCL3, CCL4, CCL5 and CCL8; upregulated CCR7 expression; and downregulated CCR2.</span>
<div><font color="#000000" face="arial, helvetica, clean, sans-serif"><span style="line-height: 19.994px;">Taqman low-density arrays for chemokine and chemokine</span></font></div><div><font color="#000000" face="arial, helvetica, clean, sans-serif"><span style="line-height: 19.994px;">receptor expression 芯片</span></font></div>
in vitro : 小鼠的骨髓细胞，干扰miR155后，对比表面趋化因子等的表达
miR124
<div class="cit" style="font-size: 0.8465em; line-height: 1.45em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;"><span role="menubar"><a href="https://www.ncbi.nlm.nih.gov/pubmed/27757114#" title="Frontiers in immunology." abstractlink="yes" alsec="jour" alterm="Front Immunol." role="menuitem" aria-expanded="false" aria-haspopup="true" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Front Immunol.</a></span> 2016 Oct 4;7:406. eCollection 2016. IF=5.69</div><h1 style="font-size: 1.3em; margin: 0.375em 0px; line-height: 1.125em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;">miRNA-<span class="highlight" style="background-color: rgb(255, 204, 255);">124</span> in Immune System and Immune Disorders.</h1><div class="auths" style="font-size: 0.923em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;"><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Qin%20Z%5BAuthor%5D&cauthor=true&cauthor_uid=27757114" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Qin Z</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">1</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Wang%20PY%5BAuthor%5D&cauthor=true&cauthor_uid=27757114" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Wang PY</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">1</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Su%20DF%5BAuthor%5D&cauthor=true&cauthor_uid=27757114" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Su DF</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">1</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Liu%20X%5BAuthor%5D&cauthor=true&cauthor_uid=27757114" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Liu X</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">1</span>.</div><div class="afflist" style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; line-height: 14.9998px; zoom: 1;"><h3 style="font-size: 1.0769em; line-height: 1.2857; margin: 0.5em 0em; color: rgb(114, 65, 40); zoom: 1;"><a class="jig-ncbitoggler ui-widget ui-ncbitoggler-open" href="https://www.ncbi.nlm.nih.gov/pubmed/27757114#" id="ui-ncbitoggler-2" role="button" aria-expanded="true" style="font-size: 13.9997px; font-family: arial, sans-serif !important; padding-left: 16px; position: relative; display: block; color: rgb(102, 0, 102); border-bottom-width: 0px; text-decoration: none !important; outline: none;" original-title="Open/close author information list"><span class="ui-ncbitoggler-master-text">Author information</span><span class="ui-icon ui-icon-triangle-1-s" style="display: inline; text-indent: -99999px; overflow: hidden; width: 16px; height: 16px; position: absolute; left: 0px; border: none; border-bottom-left-radius: 3px; border-bottom-right-radius: 3px; margin: 0px; padding: 0px; right: 0px; top: 3px; background: url(https://static.pubmed.gov/portal/portal3rc.fcgi/4143083/img/3974597) 0px 0px no-repeat scroll transparent;"></span></a></h3><div class="ui-helper-reset" aria-live="assertive" style="margin: 0px; padding: 0px; border: 0px; outline: 0px; line-height: 1.3; list-style: none;"><ul class="ui-ncbi-toggler-slave ui-ncbitoggler ui-ncbitoggler-slave-open" aria-hidden="false" style="margin-right: 0px; margin-bottom: 1.6em; margin-left: 0px; list-style-type: none; padding: 0px;"><li><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">1</span>Department of Pharmacology, School of Pharmacy, Second Military Medical University , Shanghai , China.</li></ul></div></div>
<div class="cit" style="font-size: 0.8465em; line-height: 1.45em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;"><span role="menubar"><a href="https://www.ncbi.nlm.nih.gov/pubmed/25736362/#" title="Modern rheumatology." abstractlink="yes" alsec="jour" alterm="Mod Rheumatol." role="menuitem" aria-expanded="false" aria-haspopup="true" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Mod Rheumatol.</a></span> 2015 Sep;25(5):784-9. doi: 10.3109/14397595.2015.1023887. Epub 2015 Jul 20. IF=1.8</div><h1 style="font-size: 1.3em; margin: 0.375em 0px; line-height: 1.125em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;">MicroRNA-<span class="highlight" style="background-color: rgb(255, 204, 255);">124</span> involves in ankylosing spondylitis by targeting ANTXR2.</h1><div class="auths" style="font-size: 0.923em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;"><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Xia%20Y%5BAuthor%5D&cauthor=true&cauthor_uid=25736362" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Xia Y</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">1</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Chen%20K%5BAuthor%5D&cauthor=true&cauthor_uid=25736362" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Chen K</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Zhang%20MH%5BAuthor%5D&cauthor=true&cauthor_uid=25736362" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Zhang MH</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Wang%20LC%5BAuthor%5D&cauthor=true&cauthor_uid=25736362" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Wang LC</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Ma%20CY%5BAuthor%5D&cauthor=true&cauthor_uid=25736362" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Ma CY</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Lin%20YL%5BAuthor%5D&cauthor=true&cauthor_uid=25736362" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Lin YL</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Zhao%20YR%5BAuthor%5D&cauthor=true&cauthor_uid=25736362" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Zhao YR</a>.</div>
<h3 style="font-size: 1.0769em; line-height: 1.2857; margin: 0px; color: rgb(152, 87, 53); font-weight: bold; display: inline; font-family: arial, helvetica, clean, sans-serif;">Abstract</h3><div class="" style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; line-height: 14.9998px;"><h4 style="font-size: 1em; margin: 0px 0.25em 0px 0px; color: rgb(0, 0, 0); font-weight: bold; text-transform: uppercase; float: left;">OBJECTIVES:</h4><p style="margin: 0px 0px 0.5em; line-height: 1.538em; font-size: 1.04em;"><abstracttext label="OBJECTIVES" nlmcategory="OBJECTIVE">A recent genome-wide association study or GWAS identified that anthrax roxin receptor 2 (ANTXR2) was one of the risk loci for ankylosing spondylitis (AS). Previous study also showed that ANTXR2 could potentially affect new bone formation. This study aimed to investigate the possible mechanisms of ANTXR2 involved in AS pathogenesis.</abstracttext></p><h4 style="font-size: 1em; margin: 0px 0.25em 0px 0px; color: rgb(0, 0, 0); font-weight: bold; text-transform: uppercase; float: left;">METHODS:</h4><p style="margin: 0px 0px 0.5em; line-height: 1.538em; font-size: 1.04em;"><abstracttext label="METHODS" nlmcategory="METHODS">The expression level of ANTXR2 and <span class="highlight" style="background-color: rgb(255, 204, 255);">miR</span>-<span class="highlight" style="background-color: rgb(255, 204, 255);">124</span> in peripheral blood was detected by quantitative real-time polymerase chain reaction or qRT-PCR. ANTXR2 was predicted to be a target gene of <span class="highlight" style="background-color: rgb(255, 204, 255);">miR</span>-<span class="highlight" style="background-color: rgb(255, 204, 255);">124</span> by TargetScan, which was confirmed by luciferase reporter assays. Western blot analysis was used to further investigate the effect of <span class="highlight" style="background-color: rgb(255, 204, 255);">miR</span>-<span class="highlight" style="background-color: rgb(255, 204, 255);">124</span> on c-Jun N-terminal kinase (JNK) activation and evaluate the activated status of autophagy.</abstracttext></p><h4 style="font-size: 1em; margin: 0px 0.25em 0px 0px; color: rgb(0, 0, 0); font-weight: bold; text-transform: uppercase; float: left;">RESULTS:</h4><p style="margin: 0px 0px 0.5em; line-height: 1.538em; font-size: 1.04em;"><abstracttext label="RESULTS" nlmcategory="RESULTS">We evidenced that ANTXR2 was downregulated and <span class="highlight" style="background-color: rgb(255, 204, 255);">miR</span>-<span class="highlight" style="background-color: rgb(255, 204, 255);">124</span> was upregulated in peripheral blood from AS patients. Intriguingly, <span class="highlight" style="background-color: rgb(255, 204, 255);">miR</span>-<span class="highlight" style="background-color: rgb(255, 204, 255);">124</span> targeted ANTXR2 and overexpression of <span class="highlight" style="background-color: rgb(255, 204, 255);">miR</span>-<span class="highlight" style="background-color: rgb(255, 204, 255);">124</span> in Jurkat cells notably inhibited ANTXR2 expression. ANTXR2 inhibition by <span class="highlight" style="background-color: rgb(255, 204, 255);">miR</span>-<span class="highlight" style="background-color: rgb(255, 204, 255);">124</span>promoted JNK activation and induced autophagy.</abstracttext></p><h4 style="font-size: 1em; margin: 0px 0.25em 0px 0px; color: rgb(0, 0, 0); font-weight: bold; text-transform: uppercase; float: left;">CONCLUSIONS:</h4><p style="margin: 0px 0px 0.5em; line-height: 1.538em; font-size: 1.04em;"><abstracttext label="CONCLUSIONS" nlmcategory="CONCLUSIONS">Our results suggested that <span class="highlight" style="background-color: rgb(255, 204, 255);">miR</span>-<span class="highlight" style="background-color: rgb(255, 204, 255);">124</span> might induce autophagy to participate in AS by targeting ANTXR2, which might be implicated in pathological process of AS.</abstracttext></p></div>
<div class="cit" style="font-size: 0.8465em; line-height: 1.45em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;"><span role="menubar"><a href="https://www.ncbi.nlm.nih.gov/pubmed/27709266#" abstractlink="yes" alsec="jour" alterm="J Mol Med (Berl)." role="menuitem" aria-expanded="false" aria-haspopup="true" style="color: rgb(102, 0, 102); border-bottom-width: 0px;" original-title="Journal of molecular medicine (Berlin, Germany).">J Mol Med (Berl).</a></span> 2016 Oct 5. [Epub ahead of print]</div><h1 style="font-size: 1.3em; margin: 0.375em 0px; line-height: 1.125em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;">Nicotine protects against DSS colitis through regulating microRNA-<span class="highlight" style="background-color: rgb(255, 204, 255);">124</span> and STAT3.</h1><div class="auths" style="font-size: 0.923em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;"><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Qin%20Z%5BAuthor%5D&cauthor=true&cauthor_uid=27709266" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Qin Z</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">1</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Wan%20JJ%5BAuthor%5D&cauthor=true&cauthor_uid=27709266" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Wan JJ</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">1</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Sun%20Y%5BAuthor%5D&cauthor=true&cauthor_uid=27709266" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Sun Y</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">1</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Wu%20T%5BAuthor%5D&cauthor=true&cauthor_uid=27709266" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Wu T</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">2</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Wang%20PY%5BAuthor%5D&cauthor=true&cauthor_uid=27709266" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Wang PY</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">1</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Du%20P%5BAuthor%5D&cauthor=true&cauthor_uid=27709266" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Du P</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">2</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Su%20DF%5BAuthor%5D&cauthor=true&cauthor_uid=27709266" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Su DF</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">3</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Yang%20Y%5BAuthor%5D&cauthor=true&cauthor_uid=27709266" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Yang Y</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">4</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Liu%20X%5BAuthor%5D&cauthor=true&cauthor_uid=27709266" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Liu X</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">5</span>.</div>
<div class="cit" style="font-size: 0.8465em; line-height: 1.45em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;"><span role="menubar"><a href="https://www.ncbi.nlm.nih.gov/pubmed/27786595#" title="Epigenetics." abstractlink="yes" alsec="jour" alterm="Epigenetics." role="menuitem" aria-expanded="false" aria-haspopup="true" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Epigenetics.</a></span> 2016 Oct 27:0. [Epub ahead of print]</div><h1 style="font-size: 1.3em; margin: 0.375em 0px; line-height: 1.125em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;">Cocaine-mediated downregulation of microglial <span class="highlight" style="background-color: rgb(255, 204, 255);">miR</span>-<span class="highlight" style="background-color: rgb(255, 204, 255);">124</span> expression involves promoter DNA methylation.</h1><div class="auths" style="font-size: 0.923em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;"><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Guo%20ML%5BAuthor%5D&cauthor=true&cauthor_uid=27786595" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Guo ML</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">1</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Periyasamy%20P%5BAuthor%5D&cauthor=true&cauthor_uid=27786595" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Periyasamy P</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">1</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Liao%20K%5BAuthor%5D&cauthor=true&cauthor_uid=27786595" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Liao K</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">1</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Kook%20YH%5BAuthor%5D&cauthor=true&cauthor_uid=27786595" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Kook YH</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">1</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Niu%20F%5BAuthor%5D&cauthor=true&cauthor_uid=27786595" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Niu F</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">1</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Callen%20SE%5BAuthor%5D&cauthor=true&cauthor_uid=27786595" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Callen SE</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">1</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Buch%20S%5BAuthor%5D&cauthor=true&cauthor_uid=27786595" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Buch S</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">1</span>.</div>
<div class="cit" style="font-size: 0.8465em; line-height: 1.45em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;"><span role="menubar"><a href="https://www.ncbi.nlm.nih.gov/pubmed/26700406#" title="Immunological investigations." abstractlink="yes" alsec="jour" alterm="Immunol Invest." role="menuitem" aria-expanded="false" aria-haspopup="true" style="outline: 0px; color: rgb(102, 0, 102); border-bottom-width: 0px;">Immunol Invest.</a></span> 2016;45(1):1-10. doi: 10.3109/08820139.2015.1085390. Epub 2015 Dec 23. 1.78</div><h1 style="font-size: 1.3em; margin: 0.375em 0px; line-height: 1.125em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;">Role of miR-146a in Enforcing Effect of Specific Immunotherapy on <span class="highlight" style="background-color: rgb(255, 204, 255);">Allergic Rhinitis</span>.</h1><div class="auths" style="font-size: 0.923em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;"><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Liu%20HJ%5BAuthor%5D&cauthor=true&cauthor_uid=26700406" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Liu HJ</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">1,</span><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">2</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Zhang%20AF%5BAuthor%5D&cauthor=true&cauthor_uid=26700406" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Zhang AF</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">2</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Zhao%20N%5BAuthor%5D&cauthor=true&cauthor_uid=26700406" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Zhao N</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">2</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Li%20XZ%5BAuthor%5D&cauthor=true&cauthor_uid=26700406" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Li XZ</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">1</span>.</div>
模型方法参考
<span class="highlight" style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px; background-color: rgb(255, 204, 255);">Allergic</span><span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px;"> </span><span class="highlight" style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px; background-color: rgb(255, 204, 255);">rhinitis</span><span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px;"> (AR) is one of the common disorders in airway </span><span class="highlight" style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px; background-color: rgb(255, 204, 255);">allergic</span><span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px;"> inflammation. The pathogenesis of AR is unclear. It is accepted that immune deregulation is associated with the pathogenesis of AR. Recent reports suggest that a large number of micro RNAs (miR) can regulate immune functions. This study aims to investigate the </span><span class="highlight" style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px; background-color: rgb(255, 204, 255);">role</span><span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px;"> of </span><span class="highlight" style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px; background-color: rgb(255, 204, 255);">miR-146a</span><span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px;"> in an </span><span class="highlight" style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px; background-color: rgb(255, 204, 255);">enforcing</span><span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px;"> </span><span class="highlight" style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px; background-color: rgb(255, 204, 255);">immunotherapy</span><span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px;"> of AR. In this study, a mouse AR model was created. The levels of </span><span class="highlight" style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px; background-color: rgb(255, 204, 255);">miR-146a</span><span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px;"> in the mouse nasal mucosa were assessed by real time RT-PCR. A </span><span class="highlight" style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px; background-color: rgb(255, 204, 255);">specific</span><span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px;"> </span><span class="highlight" style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px; background-color: rgb(255, 204, 255);">immunotherapy</span><span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px;"> was performed in AR mice. The results showed that the AR mice had an AR-like inflammation in the nasal mucosa. Compared with naïve mice, markedly lower levels of </span><span class="highlight" style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px; background-color: rgb(255, 204, 255);">miR-146a</span><span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px;"> were detected in AR mice. The co-administration with </span><span class="highlight" style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px; background-color: rgb(255, 204, 255);">miR-146a</span><span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px;"> significantly enforced the </span><span class="highlight" style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px; background-color: rgb(255, 204, 255);">effect</span><span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px;"> of ovalbumin (OVA)-</span><span class="highlight" style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px; background-color: rgb(255, 204, 255);">specific</span><span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px;"> </span><span class="highlight" style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px; background-color: rgb(255, 204, 255);">immunotherapy</span><span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px;">on inhibition of AR inflammation in the nasal mucosa. Further analysis showed that </span><span class="highlight" style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px; background-color: rgb(255, 204, 255);">miR-146a</span><span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px;"> induced transforming growth factor-β in dendritic cells; the latter induced naïve CD4(+) T cells to differentiate into regulatory T cells. In conclusion, </span><span class="highlight" style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px; background-color: rgb(255, 204, 255);">miR-146a</span><span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px;"> can enforce OVA-</span><span class="highlight" style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px; background-color: rgb(255, 204, 255);">specific</span><span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px;"> </span><span class="highlight" style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px; background-color: rgb(255, 204, 255);">immunotherapy</span><span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px;"> via inducing antigen-</span><span class="highlight" style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px; background-color: rgb(255, 204, 255);">specific</span><span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px;"> regulatory T cells. </span><span class="highlight" style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px; background-color: rgb(255, 204, 255);">miR-146a</span><span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px;"> may have therapeutic potential to be used in the </span><span class="highlight" style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px; background-color: rgb(255, 204, 255);">immunotherapy</span><span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px;"> of </span><span class="highlight" style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px; background-color: rgb(255, 204, 255);">allergic</span><span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px;"> diseases.</span>
经典文献
<div class="cit" style="font-size: 0.8465em; line-height: 1.45em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;"><span role="menubar"><a href="https://www.ncbi.nlm.nih.gov/pubmed/24043765#" title="The Journal of experimental medicine." abstractlink="yes" alsec="jour" alterm="J Exp Med." role="menuitem" aria-expanded="false" aria-haspopup="true" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">J Exp Med.</a></span> 2013 Sep 23;210(10):1993-2010. doi: 10.1084/jem.20121200. Epub 2013 Sep 16.</div><h1 style="font-size: 1.3em; margin: 0.375em 0px; line-height: 1.125em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;">VEGF controls lung <span class="highlight" style="background-color: rgb(255, 204, 255);">Th2</span> <span class="highlight" style="background-color: rgb(255, 204, 255);">inflammation</span> via the <span class="highlight" style="background-color: rgb(255, 204, 255);">miR</span>-1-Mpl (myeloproliferative leukemia virus oncogene)-P-selectin <span class="highlight" style="background-color: rgb(255, 204, 255);">axis</span>.</h1><div class="auths" style="font-size: 0.923em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;"><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Takyar%20S%5BAuthor%5D&cauthor=true&cauthor_uid=24043765" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Takyar S</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">1</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Vasavada%20H%5BAuthor%5D&cauthor=true&cauthor_uid=24043765" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Vasavada H</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Zhang%20JG%5BAuthor%5D&cauthor=true&cauthor_uid=24043765" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Zhang JG</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Ahangari%20F%5BAuthor%5D&cauthor=true&cauthor_uid=24043765" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Ahangari F</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Niu%20N%5BAuthor%5D&cauthor=true&cauthor_uid=24043765" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Niu N</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Liu%20Q%5BAuthor%5D&cauthor=true&cauthor_uid=24043765" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Liu Q</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Lee%20CG%5BAuthor%5D&cauthor=true&cauthor_uid=24043765" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Lee CG</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Cohn%20L%5BAuthor%5D&cauthor=true&cauthor_uid=24043765" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Cohn L</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Elias%20JA%5BAuthor%5D&cauthor=true&cauthor_uid=24043765" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Elias JA</a>.</div>
mir干预鼻部炎症的研究经典问下 -from pro li
<div class="cit" style="font-size: 0.8465em; line-height: 1.45em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;"><span role="menubar"><a href="https://www.ncbi.nlm.nih.gov/pubmed/25961389#" title="Current opinion in allergy and clinical immunology." abstractlink="yes" alsec="jour" alterm="Curr Opin Allergy Clin Immunol." role="menuitem" aria-expanded="false" aria-haspopup="true" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Curr Opin Allergy Clin Immunol.</a></span> 2015 Apr;15(2):156-62. doi: 10.1097/ACI.0000000000000147. IF =2.7</div><h1 style="font-size: 1.3em; margin: 0.375em 0px; line-height: 1.125em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;"><span class="highlight" style="background-color: rgb(255, 204, 255);">Role</span> of <span class="highlight" style="background-color: rgb(255, 204, 255);">microRNAs</span> in <span class="highlight" style="background-color: rgb(255, 204, 255);">allergic</span> <span class="highlight" style="background-color: rgb(255, 204, 255);">asthma</span>: present and future.</h1><div class="auths" style="font-size: 0.923em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;"><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Perry%20MM%5BAuthor%5D&cauthor=true&cauthor_uid=25961389" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Perry MM</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">1</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Adcock%20IM%5BAuthor%5D&cauthor=true&cauthor_uid=25961389" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Adcock IM</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Chung%20KF%5BAuthor%5D&cauthor=true&cauthor_uid=25961389" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Chung KF</a>.</div>
<div class="cit" style="font-size: 0.8465em; line-height: 1.45em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;"><span role="menubar"><a href="https://www.ncbi.nlm.nih.gov/pubmed/24373357#" title="The Journal of allergy and clinical immunology." abstractlink="yes" alsec="jour" alterm="J Allergy Clin Immunol." role="menuitem" aria-expanded="false" aria-haspopup="true" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">J Allergy Clin Immunol.</a></span> 2014 May;133(5):1429-38, 1438.e1-7. doi: 10.1016/j.jaci.2013.11.008. Epub 2013 Dec 24.</div><h1 style="font-size: 1.3em; margin: 0.375em 0px; line-height: 1.125em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;">MicroRNA-155 is essential for T(H)2-mediated allergen-induced eosinophilic inflammation in the lung.</h1><div class="auths" style="font-size: 0.923em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;"><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Malmh%C3%A4ll%20C%5BAuthor%5D&cauthor=true&cauthor_uid=24373357" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Malmhäll C</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">1</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Alawieh%20S%5BAuthor%5D&cauthor=true&cauthor_uid=24373357" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Alawieh S</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">1</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Lu%20Y%5BAuthor%5D&cauthor=true&cauthor_uid=24373357" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Lu Y</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">1</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Sj%C3%B6strand%20M%5BAuthor%5D&cauthor=true&cauthor_uid=24373357" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Sjöstrand M</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">1</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Bossios%20A%5BAuthor%5D&cauthor=true&cauthor_uid=24373357" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Bossios A</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">1</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Eldh%20M%5BAuthor%5D&cauthor=true&cauthor_uid=24373357" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Eldh M</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">1</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=R%C3%A5dinger%20M%5BAuthor%5D&cauthor=true&cauthor_uid=24373357" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Rådinger M</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">2</span>.</div>
<p style="margin: 0px 0px 0.5em; line-height: 1.538em; font-size: 1.04em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;"><abstracttext label="METHODS" nlmcategory="METHODS">To investigate a role for <span class="highlight" style="background-color: rgb(255, 204, 255);">miR</span>-155 in the regulation of <span class="highlight" style="background-color: rgb(255, 204, 255);">allergic</span> inflammation in vivo, we used <span class="highlight" style="background-color: rgb(255, 204, 255);">miR</span>-155 knockout (KO) and wild-type (WT) mice sensitized and exposed to ovalbumin.</abstracttext></p><h4 style="margin: 0px 0.25em 0px 0px; color: rgb(0, 0, 0); font-weight: bold; text-transform: uppercase; float: left; font-family: arial, helvetica, clean, sans-serif; line-height: 14.9998px;">RESULTS:</h4><p style="margin: 0px 0px 0.5em; line-height: 1.538em; font-size: 1.04em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;"><abstracttext label="RESULTS" nlmcategory="RESULTS"><span class="highlight" style="background-color: rgb(255, 204, 255);">miR</span>-155 deficiency resulted in diminished eosinophilic inflammation and mucus hypersecretion in the lungs of allergen-sensitized and allergen-challenged mice compared with WT control animals. This was supported by a reduction in T(H)2 cell numbers and airway T(H)2 cytokine levels and complete abrogation of allergen-induced airway eotaxin-2/CCL24 and periostin levels in <span class="highlight" style="background-color: rgb(255, 204, 255);">miR</span>-155 KO mice. Intranasal instillation of eotaxin-2/CCL24 before allergen challenge partially restored airway eosinophilia in <span class="highlight" style="background-color: rgb(255, 204, 255);">miR</span>-155 KO mice, and adoptive transfer of CD4(+) T cells resulted in a similar degree of airway eosinophilia in <span class="highlight" style="background-color: rgb(255, 204, 255);">miR</span>-155 KO and WT mice. Furthermore, the transcription factor PU.1, a negative regulator of T(H)2 cytokine production, was upregulated in the airways of allergen-challenged <span class="highlight" style="background-color: rgb(255, 204, 255);">miR</span>-155 KO mice compared with WT mice.</abstracttext></p><h4 style="margin: 0px 0.25em 0px 0px; color: rgb(0, 0, 0); font-weight: bold; text-transform: uppercase; float: left; font-family: arial, helvetica, clean, sans-serif; line-height: 14.9998px;">CONCLUSIONS:</h4><p style="margin: 0px 0px 0.5em; line-height: 1.538em; font-size: 1.04em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;"><abstracttext label="CONCLUSIONS" nlmcategory="CONCLUSIONS">Our data provides evidence that <span class="highlight" style="background-color: rgb(255, 204, 255);">miR</span>-155 contributes to the regulation of <span class="highlight" style="background-color: rgb(255, 204, 255);">allergic</span> airway inflammation by modulating T(H)2 responses through the transcription fac</abstracttext></p>
<div class="cit" style="font-size: 0.8465em; line-height: 1.45em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;"><span role="menubar"><a href="https://www.ncbi.nlm.nih.gov/pubmed/27187364#" title="International journal of molecular sciences." abstractlink="yes" alsec="jour" alterm="Int J Mol Sci." role="menuitem" aria-expanded="false" aria-haspopup="true" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Int J Mol Sci.</a></span> 2016 May 12;17(5). pii: E716. doi: 10.3390/ijms17050716. 刘争教授的综述，好好看</div><h1 style="font-size: 1.3em; margin: 0.375em 0px; line-height: 1.125em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;">MicroRNA in United Airway Diseases.</h1><div class="auths" style="font-size: 0.923em; color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif;"><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Liu%20Z%5BAuthor%5D&cauthor=true&cauthor_uid=27187364" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Liu Z</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">1</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Zhang%20XH%5BAuthor%5D&cauthor=true&cauthor_uid=27187364" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Zhang XH</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">2</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Callejas-D%C3%ADaz%20B%5BAuthor%5D&cauthor=true&cauthor_uid=27187364" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Callejas-Díaz B</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">3</span>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Mullol%20J%5BAuthor%5D&cauthor=true&cauthor_uid=27187364" style="color: rgb(102, 0, 102); border-bottom-width: 0px;">Mullol J</a><span style="font-size: 0.8461em; line-height: 1.6363em; position: relative; vertical-align: baseline; top: -0.5em;">4</span>.</div>
<span style="color: rgb(0, 0, 0); font-family: arial, helvetica, clean, sans-serif; font-size: 13.52px; line-height: 20.7938px;">The concept of united airway diseases (UAD) has received increasing attention in recent years. Sustained and increased inflammation is a common feature of UAD, which is inevitably accompanied with marked gene modification and tight gene regulation. However, gene regulation in the common inflammatory processes in UAD remains unclear. MicroRNA (miRNA), a novel regulator of gene expression, has been considered to be involved in many inflammatory diseases. Although there are an increasing number of studies of miRNAs in inflammatory upper and lower airway diseases, few miRNAs have been identified that directly link the upper and lower airways. In this article, therefore, we reviewed the relevant studies available in order to improve the understanding of the roles of miRNAs in the interaction and pathogenesis of UAD.</span>
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