tissue validation
internal validation
Filtering out 2 miRNAs that exhibitedvery low expression in serum and 2 other miRNAs that werehighly correlated with other miRNAs
diagnostic performance of the discovered miRNA candidates
9 miRNAs
logit(P) = (−0.2941 + (0.5042 × miR-18a) + (0.1351 × miR-181b) + (0.1130 × miR-335)).
TCGA
8 miRNAs
logistic regression withelastic net regularization and bootstrapping
multivariate logistic regression and derived model
external validation
biomarker discover
retrospective serum validation
miRNA-based signature for the early detection of GC
3 miRNAs
prospective serum performance evaluation
qRT-PCR
50 pairs
5 miRNAs
10 miRNAs
