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cryptococcus neoformans

2016-12-28 21:46:14   0  举报

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undone-cryptococcus

capsule

virulence factor

oxidative burst

phagocytes

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作者其他创作

大纲/内容

host defense

innate

phagocytosis

procedures

子主题

adaptive

virulence factors

others

laccase

sequester iron during infection

interfere with oxidative burst

nvolved in the production of melanin

melanin

capture free radicals

catalase

destroy H2O2

catalase test

capsule

components

rich in clucuronic acid and mannose, O-acetul groups

GXM

glucuronic acid, mannose and xylose

can elicit protective antibodies when coupled to proteins

GalXM

mannose galactose and xylose and glucoronic acids

mannoproteins

stimulate TLR2 and TLR9, increased phagocytosis

capsule components

inhibit production of proinflammatory cytokines

deplete complement components (binding)

reduce leukocyte migration to inflammation sites

diagnostic features

ELISA serum

india ink stain

hh:) capsule syn is induced when infected

acapsular mutants

capsule intergal physical

protect against phagocytosis and oxidative burst

prevent interaction of fungus surface protein with adaptive immune system

disease: cryptococcsis

at risk

tropism for CNS

immuocompromised

HIV/AIDS

transplants

chemotherapy/cancer

OR; cleared until imbalance

sources

bird droppings

eucalyptus trees

decaying wood

transmission

NON-COMMUNICABLE in humans

human-only natural host

desiccated cells and spores as infective particles

signs and symptoms

peumonia-like illness

chest pain<br>

cough fever weight loss

meningoencephalitis

CNS

inflammation of brain and meninges

fever headache lethargy mental status

may permanent

cutaneous cryptococcosis

lab cahracterization

microscopic examination

blood and serespinal fluild

cryptococcal antigen test

capsule polysaccharide

fungal culture

differentiate species of C.

india ink

negative

capsule halo

treatment

antifungal>6 months

amphotericin B

binds to ergosterol

combined with flucytosine

target RNA/DNA syn

severe

fulconazole/itraconazole

targets ergosterol synthesis

mild/moderate

子主题

pathogen

basics

Phylum - Basidiomycota

spores formed in basidum

dimorphic life cycle

monokaryotic yeast

dikaryotic hyphal

sexual and asexual life cycle

life cycle

C.neoformans

polysaccharide capsule

the ONLY ENCAPSULATED human pathogen

reproduction

asex (bud)

sex

basidium

end of hyphae

spore producing

respiratory

reside in alveoli

cell wall contains melanin

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