cryptococcus neoformans

procedures

sequester iron during infection

interfere with oxidative burst

nvolved in the production of melanin

capture free radicals

destroy H2O2

catalase test

rich in clucuronic acid and mannose, O-acetul groups

GXM

GalXM

mannoproteins

stimulate TLR2 and TLR9, increased phagocytosis

inhibit production of proinflammatory cytokines

deplete complement components (binding)

reduce leukocyte migration to inflammation sites

ELISA serum

india ink stain

hh:) capsule syn is induced when infected

protect against phagocytosis and oxidative burst

prevent interaction of fungus surface protein with adaptive immune system

immuocompromised

human-only natural host

chest pain

cough fever weight loss

CNS

blood and serespinal fluild

capsule polysaccharide

differentiate species of C.

negative

binds to ergosterol

combined with flucytosine

severe

targets ergosterol synthesis

mild/moderate

spores formed in basidum

dimorphic life cycle

sexual and asexual life cycle

the ONLY ENCAPSULATED human pathogen

asex (bud)

sex

end of hyphae

spore producing