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food poisoning

2016-12-27 20:08:57   0  举报

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food poisoning and intoxication

food-borne disease

C.botulism

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作者其他创作

大纲/内容

prevention

转让

ten golden rules

processed safety

cook

eat immediately

store

reheat thoroughly

no contact with raw

wash hands

potable water

pest protect

food-borne intoxication

toxin ingested

C.botulinum

neurotoxin

heavy chain

target axon terminals of neurons

then toxin is endocytosized by neurons

light chain

proteolytically degrade SNAP-25 (one type of SNARE)

prevent neurosecretory vesicles from docking/fusing iwth nerve synapse plasma

flaccid paralysis

basics

firmicutes

potent neurotoxins

ABCD 4 serologically distinct toxins

lead to flaccid paralysis

Multiplex PCR system

symptoms

16h

blurred vision

difficulties in swallowing and speaking

muscle weakness

days

die of cardiac / resp. failure

staphylococcus aureus

bacillus cereus

toxin released after ingestion of cells

C.perfringens

basics

common in soil and lower intestine (non-pathogenic)

obligatory anaerobic

high infective dose

change in pH induce sporulation release toxin

pores survive cooking, may germinate when not freeze

toxins elaborate in intestinal tract, cause increased fluid and electrolyte secretion

heat shock - spore germinate

food-borne diseases

food is vector

onset by vomiting nad diarrhea

classification

food-borne infection

etiologic agents are viable pathogenic organisms

communicable

slower

food-borne intoxication

ingestion of toxins released by microorganisms

sensory motor dysfunction / resp. failure numbness

non-comm

faster

gastrointestinal defense

compartments

stomach

acid and proteases

small intestine

bile containing

alkaline

digestive enzymes

detergents for fats

large intestine (colon)

digestion of polysaccharides

desquamated cells

production of short chain fatty acids

food-borne infection

Listeria. monocytogenes

basics

phylum: firmicutes

G positive

anaerobic/aerobic

disease:  listeriosis

live better than other bacteria in refrigerator

found in raw foods

pregnant woman at risk

immunocompromised

elderly people

listeriosis

diagnosis

blood and spinal sample

treatment

antibiotics

transmission

actin filaments

ActA protein from listeria interact with actin filaments

other gram negative, facultative anaerobic

C. jejuni

salmonella

motile , non capsulated, non-sporulating

cause enteric fever

fecal pollution

localised inflammation of small intestine, lysis of bacteria releasing toxins

virulence factor

adhesins

e.g. Type 1 fimbriae

e.g. surface appendage

impedins

Vi capsule antigen: complement

O antigen: inhibit phagocyte killing

toxins

cytotoxins

enterotoxin

E.coli

Yersinica enterocolitica

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