food poisoning
2016-12-27 20:08:57 0 举报AI智能生成
food poisoning and intoxication
作者其他创作
大纲/内容
prevention
转让
ten golden rules
processed safety
cook
eat immediately
store
reheat thoroughly
no contact with raw
wash hands
potable water
pest protect
food-borne intoxication
toxin ingested
C.botulinum
neurotoxin
heavy chain
target axon terminals of neurons
then toxin is endocytosized by neurons
light chain
proteolytically degrade SNAP-25 (one type of SNARE)
prevent neurosecretory vesicles from docking/fusing iwth nerve synapse plasma
flaccid paralysis
basics
firmicutes
potent neurotoxins
ABCD 4 serologically distinct toxins
lead to flaccid paralysis
Multiplex PCR system
symptoms
16h
blurred vision
difficulties in swallowing and speaking
muscle weakness
days
die of cardiac / resp. failure
staphylococcus aureus
bacillus cereus
toxin released after ingestion of cells
C.perfringens
basics
common in soil and lower intestine (non-pathogenic)
obligatory anaerobic
high infective dose
change in pH induce sporulation release toxin
pores survive cooking, may germinate when not freeze
toxins elaborate in intestinal tract, cause increased fluid and electrolyte secretion
heat shock - spore germinate
food-borne diseases
food is vector
onset by vomiting nad diarrhea
classification
food-borne infection
etiologic agents are viable pathogenic organisms
communicable
slower
food-borne intoxication
ingestion of toxins released by microorganisms
sensory motor dysfunction / resp. failure numbness
non-comm
faster
gastrointestinal defense
compartments
stomach
acid and proteases
small intestine
bile containing
alkaline
digestive enzymes
detergents for fats
large intestine (colon)
digestion of polysaccharides
desquamated cells
production of short chain fatty acids
food-borne infection
Listeria. monocytogenes
basics
phylum: firmicutes
G positive
anaerobic/aerobic
disease: listeriosis
live better than other bacteria in refrigerator
found in raw foods
pregnant woman at risk
immunocompromised
elderly people
listeriosis
diagnosis
blood and spinal sample
treatment
antibiotics
transmission
actin filaments
ActA protein from listeria interact with actin filaments
other gram negative, facultative anaerobic
C. jejuni
salmonella
motile , non capsulated, non-sporulating
cause enteric fever
fecal pollution
localised inflammation of small intestine, lysis of bacteria releasing toxins
virulence factor
adhesins
e.g. Type 1 fimbriae
e.g. surface appendage
impedins
Vi capsule antigen: complement
O antigen: inhibit phagocyte killing
toxins
cytotoxins
enterotoxin
E.coli
Yersinica enterocolitica
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