Study population
AIS with LVO tearted with MT after MRI
这个大的研究项目纳入时未指定前循环或后循环，但后面结果部分需要排除后循环<br><b style=""><font color="#ff0000">目前大部分取栓研究FR预测因素都针对的前循环</font></b>
Exclusion criteria
Inflammatory disease
Active malignancy
Vasculitis
Antibiotics at admission
Myocardial infarction or major surgery in the 30 previous days
<b>Blood Sample</b>
Collected at admission before IVT, 6h, 24h,48h and 3-months from admission
A CT scan was performed at day 1 and a follow-up MRI at day 6
Data recording
Baseline data
Demographic characteristics
Medical history including risk factors
Baseline neurological status
NIHSS score
mRS score——face-to-face follow-up visit at 3-month
Standard Protocol Approvals, Registrations, and Patient Consents
Neuroimaging
MRI at Day 1 (on admission)
T2，FLAIR，DWI，MRA，PWI
CT at Day 1
To identify sICH according to ECASS II
Fina MRI at 1-month
To map the final infarct on FLAIR
Follow-up MRI at Day 7
Blind evaluation (Experse who donot know clinical data )
<b>ASPECT score</b> and<b> baseline volume</b> on the DWI-sequence as well as <b>final volumes</b> on the FLAIR-sequence were measured
<b>Infarct growth</b>——the difference between final and baseline volume
Pretreatment collateral status
Poor (Higashida score 0-2)
Good (Higashida score 3-4)
<font color="#ff0000">取栓前做MR检查评ASPECTS评分和基线梗死体积，取栓后的CT检查排除sICH，第6天对MRI进行随访评估随访梗死体积。第30天再确定最终梗死范围</font>
Blood Sampling Protocol
WBC and hsCRP were measured at admission
IL-6 was measured by ELISA kit
Statistical Analysis
Spearman rank
IL-6 levels and MRI parameters
Singel-variable and multivariable logistic regression
Assessing independent markers of futile reperfusion in SR patiens
Factors with a significant connection with FR in singel-variable model were included in multivariable model
Grouping
<font color="#ff0000">IL-6</font>, hsCRP and WBC were dichotomized by <font color="#ff0000">median</font>
Avoiding collinearity
ICA and tandem occlusion
Baseline lesion volume and infarct growth
ROC curve to predict FR
<font face="微软雅黑"><b>模型1：</b></font>Age, baseline NIHSS score and baseline lesion volume
<b>模型2：</b>Age, baseline NIHSS score and baseline lesion volume + IL-6 at 24h
这一段不太懂；关于24h的IL-6缺失值用上一或下一检测点填补，否则使用中位数填补
