经皮给药制剂
2016-12-07 20:17:43 0 举报仅支持查看
AI智能生成
经皮给药制剂是一种通过皮肤直接将药物输送到体内的新型给药方式。与传统的口服、注射等给药方式相比，经皮给药具有便捷、无创、副作用小等优点。该制剂通常由药物、载体和背衬层组成，其中药物是治疗疾病的关键成分，载体用于增强药物的渗透性和吸收性，背衬层则起到保护药物和皮肤的作用。经皮给药制剂广泛应用于各种疾病的治疗，如心血管疾病、糖尿病、哮喘等。随着科技的不断进步，经皮给药制剂的研究和应用前景将会更加广阔。
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大纲/内容
TDDS一般是指经皮给药新剂型，即贴剂，而广义的经皮给药制剂包括软膏剂、硬膏剂、巴布剂和贴剂，还有涂剂、气雾剂、喷雾剂、泡沫剂和微型海绵剂等
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:Arial;
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zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">经皮给药制剂的特点</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:仿宋_GB2312;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:
zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">优点</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><font color="#0d0d0d" face="仿宋_GB2312">直接作用于靶部位发挥药效</font><br></p>
<span style="font-family:仿宋_GB2312;mso-ascii-font-family:
"Times New Roman";mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;
mso-bidi-theme-font:minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:
12.0pt;language:zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:
text2;mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">避免肝脏的首过效应和胃肠因素的干扰</span>
<span style="font-family:仿宋_GB2312;mso-ascii-font-family:
"Times New Roman";mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;
mso-bidi-theme-font:minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:
12.0pt;language:zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:
text2;mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">避免药物对胃肠道的副作用</span>
长时间维持恒定的血药浓度，避免峰谷现象，降低药物毒副作用
<span style="font-family:仿宋_GB2312;mso-ascii-font-family:
"Times New Roman";mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;
mso-bidi-theme-font:minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:
12.0pt;language:zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:
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mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">减少给药次数，而且患者可以自主用药，特别适合于婴儿、老人及不宜口服给药的患者，提高患者的用药依从性</span>
发现副作用时，可随时中断给药
<div>缺点</div><div><br></div>
<span style="color: rgb(13, 13, 13); font-family: 仿宋_GB2312; font-size: 13.3333px;">不适合剂量大或对皮肤产生刺激的药物</span>
<span style="font-family:仿宋_GB2312;mso-ascii-font-family:
"Times New Roman";mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;
mso-bidi-theme-font:minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:
12.0pt;language:zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:
text2;mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">由于起效较慢，不适合要求起效快的药物</span>
药物吸收的个体差异和给药部位的差异较大
<div>药物经皮吸收途径</div><div><br></div>
经表皮途径
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:
zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">是指药物透过表皮角质层进入活性表皮，扩散至真皮被毛细血管吸收进入体循环的途径。</span><span style="font-family:"Times New Roman";mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:
en-US;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">——</span><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:
zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">药物经皮吸收的主要途径</span></p>
<span style="font-family:仿宋_GB2312;mso-ascii-font-family:
"Times New Roman";mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;
mso-bidi-theme-font:minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:
12.0pt;language:zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:
text2;mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">② 经附属器途径</span>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:
zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">是指药物通过毛囊、皮脂腺和汗腺吸收。</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:"Times New Roman";mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:
zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000""> </span><span style="font-family:"Times New Roman";
mso-ascii-font-family:"Times New Roman";mso-fareast-font-family:仿宋_GB2312;
mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:minor-bidi;color:#0D0D0D;
mso-color-index:3;mso-font-kerning:12.0pt;language:en-US;mso-style-textfill-type:
solid;mso-style-textfill-fill-themecolor:text2;mso-style-textfill-fill-color:
#0D0D0D;mso-style-textfill-fill-alpha:100.0%;mso-style-textfill-fill-colortransforms:
"lumm=95000 lumo=5000"">——</span><span style="font-family:仿宋_GB2312;mso-ascii-font-family:
"Times New Roman";mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;
mso-bidi-theme-font:minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:
12.0pt;language:zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:
text2;mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">穿透速度比经表皮途径快，但皮肤附属器仅占角质层面积的</span><span style="font-family:"Times New Roman";mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:
en-US;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">1%</span><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:
zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">左右，不是药物经皮吸收的主要途径</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:Arial;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:
zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">影响药物经皮吸收的因素</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:Arial;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:
zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">生理因素</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:Arial;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
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zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">药物理化性质</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:Arial;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
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zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">剂型因素</span></p>
<div>选择药物的原则</div><div><br></div>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:仿宋_GB2312;
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zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">剂量</span><span style="font-family:"Times New Roman";mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:
en-US;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">——</span><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:
zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">药物剂量要小、药理作用强，日剂量</span><span style="font-family:"Times New Roman";mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:
en-US;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000""><</span><span style="font-family:"Times New Roman";mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:
en-US;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">10mg</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:仿宋_GB2312;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:
zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">物理化学性质</span><span style="font-family:"Times New Roman";mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
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en-US;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">——</span><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:
zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">相对分子质量、油水分配系数对数值、熔点等</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:仿宋_GB2312;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:
zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">生物学性质</span><span style="font-family:"Times New Roman";mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:
en-US;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">——</span><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:
zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">生物半衰期短，对皮肤无刺激，不发生过敏反应</span></p>
经皮给药贴剂的质量控制
<div>体外评价方法</div><div><br></div>
<div>试验装置、离体皮肤的制备及保管方法、接收液的选择、</div><div><span class="Apple-tab-span" style="white-space:pre"> </span> 温度的控制、数据处理</div><div><br></div>
<div>体内药物动力学评价方法</div><div><br></div>
血药法、尿药法、血药加尿药法
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:Arial;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:
zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">贴剂的质量要求</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:"Times New Roman";mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:
zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000""> 外观、残留溶剂含量测定、黏附力测定、释放度测定、</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:"Times New Roman";mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:
zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">
含量均匀度测定、微生物限度</span></p>
经皮给药系统或经皮治疗系统是指药物以一定的速率透过皮肤经毛细血管吸收进入体循环的一类制剂。
药物经皮吸收方法
<div><p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:仿宋_GB2312;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:
zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">物理方法</span></p></div>
<span style="font-family:仿宋_GB2312;mso-ascii-font-family:
"Times New Roman";mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;
mso-bidi-theme-font:minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:
12.0pt;language:zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:
text2;mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">离子导入</span>
超声导入
<span style="font-family:仿宋_GB2312;mso-ascii-font-family:
"Times New Roman";mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;
mso-bidi-theme-font:minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:
12.0pt;language:zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:
text2;mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">微针</span>
<span style="font-family:仿宋_GB2312;mso-ascii-font-family:
"Times New Roman";mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;
mso-bidi-theme-font:minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:
12.0pt;language:zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:
text2;mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">电致孔</span>
<span style="font-family:仿宋_GB2312;mso-ascii-font-family:
"Times New Roman";mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;
mso-bidi-theme-font:minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:
12.0pt;language:zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:
text2;mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">无针注射给药系统</span>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:仿宋_GB2312;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:
zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">药剂学方法</span></p>
<span style="font-family:仿宋_GB2312;mso-ascii-font-family:
"Times New Roman";mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;
mso-bidi-theme-font:minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:
12.0pt;language:zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:
text2;mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">主要借助于微米或纳米药物载体</span>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:Arial;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:
zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">经皮给药贴剂的种类</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:Arial;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:
zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">组成</span><span style="font-family:"Times New Roman";mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:
en-US;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">——</span><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:
zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">背衬膜、含药基质、胶黏剂和防黏层</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:Arial;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:
zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">分类</span></p>
<font color="#0d0d0d" face="仿宋_GB2312">按结构分类</font>
<span style="font-family:仿宋_GB2312;mso-ascii-font-family:
"Times New Roman";mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;
mso-bidi-theme-font:minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:
12.0pt;language:zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:
text2;mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">储库型</span>
<span style="font-family:仿宋_GB2312;mso-ascii-font-family:
"Times New Roman";mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;
mso-bidi-theme-font:minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:
12.0pt;language:zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:
text2;mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">骨架型</span>
<div>按基质分类</div><div><br></div>
<div>贴剂——基质为压敏胶</div><div><br></div>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";<br>mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:<br>minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:<br>zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;<br>mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;<br>mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">巴布剂</span><span style="font-family:"Times New Roman";mso-ascii-font-family:"Times New Roman";<br>mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:<br>minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:<br>en-US;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;<br>mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;<br>mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">——</span><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";<br>mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:<br>minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:<br>zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;<br>mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;<br>mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">基质为水溶性高分子材料</span></p>
<div>经皮给药贴剂的辅助材料</div><div><br></div>
<span style="font-family:仿宋_GB2312;mso-ascii-font-family:
"Times New Roman";mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;
mso-bidi-theme-font:minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:
12.0pt;language:zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:
text2;mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;
mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">压敏胶</span>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";<br>mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:<br>minor-bidi;color:#0D0D0D;mso-color-index:3;mso-font-kerning:12.0pt;language:<br>zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;<br>mso-style-textfill-fill-color:#0D0D0D;mso-style-textfill-fill-alpha:100.0%;<br>mso-style-textfill-fill-colortransforms:"lumm=95000 lumo=5000"">是对压力敏感的胶黏剂，无需借助溶剂、热或其它手段，只需施加轻度指压，即可与被黏物牢固黏合的胶黏剂</span></p>
<font color="#0d0d0d" face="仿宋_GB2312">系统组件材料</font>
<font color="#0d0d0d" face="仿宋_GB2312">背衬材料</font>
控释膜
<font color="#0d0d0d" face="仿宋_GB2312">骨架和储库材料</font>
<font color="#0d0d0d" face="仿宋_GB2312">防黏层材料</font>
姓名：谭畅
班级：制药升14级
学号：2016520461
职业：暂无
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