药物制剂新技术与新剂型
2016-12-10 18:34:41 0 举报仅支持查看
AI智能生成
药物制剂新技术与新剂型是医药领域的重要研究方向，它通过创新的药物设计和制备技术，开发出具有更好疗效、更安全、更便利的新型药物。这些新技术和新剂型包括但不限于纳米药物、生物可降解药物、控释药物、靶向药物等。它们不仅可以提高药物的治疗效果，减少副作用，还可以改善药物的服用方式和便利性，如口服给药、皮肤给药、眼用给药等。此外，新型药物制剂还可以通过改变药物的物理化学性质，提高药物的稳定性和生物利用度，从而提高药物的疗效。总的来说，药物制剂新技术与新剂型的研究和开发，对于提高人类的生活质量和健康水平具有重要意义。
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大纲/内容
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:Arial;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">研究固体分散体的意义</span></p>
<span style="font-family:"Times New Roman";mso-ascii-font-family:<br>"Times New Roman";mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;<br>mso-bidi-theme-font:minor-bidi;color:black;mso-color-index:3;mso-font-kerning:<br>12.0pt;language:zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:<br>text2;mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%"> 将难溶性的药物高度分散，从而提高药物的溶解能力</span>
<p style="margin-top: 0pt; margin-bottom: 0pt; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:黑体;mso-fareast-font-family:
仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:minor-bidi;
color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">固体分散体的制备</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:Verdana;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">制备过程</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">两个阶段</span><span style="font-family:"Times New Roman";mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:en-US;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">——</span><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">药物的分散和固化过程</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">分散法</span><span style="font-family:"Times New Roman";mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:en-US;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">——</span><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">熔融分散法、溶剂分散法、机械分散法</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">固化法</span><span style="font-family:"Times New Roman";mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:en-US;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">——</span><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">溶剂蒸发法、熔融液骤冷法</span></p>
<div><p style="margin-top: 0pt; margin-bottom: 0pt; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:黑体;mso-fareast-font-family:<br>仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:minor-bidi;<br>color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;<br>mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;<br>mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">固体分散体的制备</span></p></div>
<span style="font-family:仿宋_GB2312;mso-ascii-font-family:
"Times New Roman";mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;
mso-bidi-theme-font:minor-bidi;color:black;mso-color-index:3;mso-font-kerning:
12.0pt;language:zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:
text2;mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">熔融法</span>
<span style="font-family:仿宋_GB2312;mso-ascii-font-family:
"Times New Roman";mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;
mso-bidi-theme-font:minor-bidi;color:black;mso-color-index:3;mso-font-kerning:
12.0pt;language:zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:
text2;mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">将药物与载体材料加热至熔融、混匀，在剧烈搅拌下迅速冷却固化，或将熔融物倾倒在不锈钢板上成薄层，迅速冷却固化</span>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">特点</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">操作简单、经济，多用于热稳定的药物及低熔点的载体材料</span></p>
<span style="font-family:仿宋_GB2312;mso-ascii-font-family:
"Times New Roman";mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;
mso-bidi-theme-font:minor-bidi;color:black;mso-color-index:3;mso-font-kerning:
12.0pt;language:zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:
text2;mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">溶剂法</span>
称共沉淀法或共蒸发法。将药物和载体材料共同溶解于适宜的有机溶剂中，或分别溶于有机溶剂后再混合均匀，蒸去溶剂使药物与载体材料同时析出，得到的共沉淀物经干燥即得固体分散体
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">特点</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">避免高热，适用于对热不稳定的药物；但使用有机溶剂成本高，较难除尽，存在残留溶剂问题和使药物重结晶而降低药物分散度的隐患</span></p>
<p style="margin-top: 0pt; margin-bottom: 0pt; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:黑体;mso-fareast-font-family:
仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:minor-bidi;
color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">固体分散体的物相鉴定</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:Verdana;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">原因</span></p>
<div>制得固体分散体后必须进行物相鉴定，以确定药物在载体中的的分散状态</div><div><br></div>
<div>贮存过程中容易出现老化问题造成物相的改变，可借助物相鉴定方法了解分散状态的变化</div><div><br></div>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:Arial;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">方法</span></p>
<div>溶出速率测定</div><div><br></div>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:Arial;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">热分析法</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:Arial;mso-ascii-font-family:Arial;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:en-US;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">X-</span><span style="font-family:仿宋_GB2312;mso-ascii-font-family:Arial;mso-fareast-font-family:
仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:minor-bidi;
color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">射线衍射法</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:Arial;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">红外光谱</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:Arial;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">拉曼光谱</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:Arial;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">固相核磁共振法</span></p>
固体分散体
是指药物高度分散在适宜的载体材料中形成的一种固态物质，又称固体分散物。——分散介质为固态的载体材料
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:Arial;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">三个发展阶段</span></p>
<div>以尿素等结晶性物质为载体材料的第一代</div><div><br></div>
<div>以聚维酮、聚乙二醇等水溶性聚合物为载体材料的第二代</div><div><br></div>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:仿宋_GB2312;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">以表面活性剂为载体材料的第三代</span></p>
<div>特点</div><div><br></div>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:仿宋_GB2312;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">可将难溶性药物高度分散于固体载体中</span></p>
<div>大大提高药物的溶出速率，从而提高药物的口服吸收与生物利用度</div><div><br></div>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:仿宋_GB2312;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">可用于油性药物的固体化</span></p>
<div>难溶性药物以速释为目的时，所用载体以水溶性材料为宜，如果以缓释或肠溶为目的时，可适当使用难溶性或肠溶性高分子材料</div><div><br></div>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:Arial;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">主要问题</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:仿宋_GB2312;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">载药量小</span><span style="font-family:仿宋_GB2312;mso-ascii-font-family:仿宋_GB2312;mso-fareast-font-family:
仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:minor-bidi;
color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:en-US;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">——</span><span style="font-family:仿宋_GB2312;mso-ascii-font-family:仿宋_GB2312;mso-fareast-font-family:
仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:minor-bidi;
color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">需大量载体材料才能达到理想的溶出效果，不适用于剂量较大的难溶性药物</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:仿宋_GB2312;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">物理稳定性差</span><span style="font-family:仿宋_GB2312;mso-ascii-font-family:仿宋_GB2312;mso-fareast-font-family:
仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:minor-bidi;
color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:en-US;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">——</span><span style="font-family:仿宋_GB2312;mso-ascii-font-family:仿宋_GB2312;mso-fareast-font-family:
仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:minor-bidi;
color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">高能不稳定态；晶核</span><span style="font-family:Wingdings;mso-ascii-font-family:仿宋_GB2312;mso-fareast-font-family:
仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:minor-bidi;
color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:en-US;
mso-char-type:symbol;mso-symbol-font-family:Wingdings;mso-style-textfill-type:
solid;mso-style-textfill-fill-themecolor:text2;mso-style-textfill-fill-color:
black;mso-style-textfill-fill-alpha:100.0%">à</span><span style="font-family:
仿宋_GB2312;mso-ascii-font-family:仿宋_GB2312;mso-fareast-font-family:仿宋_GB2312;
mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:minor-bidi;color:black;
mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;mso-style-textfill-type:
solid;mso-style-textfill-fill-themecolor:text2;mso-style-textfill-fill-color:
black;mso-style-textfill-fill-alpha:100.0%">晶粒</span><span style="font-family:
Wingdings;mso-ascii-font-family:仿宋_GB2312;mso-fareast-font-family:仿宋_GB2312;
mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:minor-bidi;color:black;
mso-color-index:3;mso-font-kerning:12.0pt;language:en-US;mso-char-type:symbol;
mso-symbol-font-family:Wingdings;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:
text2;mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">à</span><span style="font-family:仿宋_GB2312;mso-ascii-font-family:仿宋_GB2312;mso-fareast-font-family:
仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:minor-bidi;
color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">稳定晶型</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:仿宋_GB2312;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">工业化生产困难</span><span style="font-family:仿宋_GB2312;mso-ascii-font-family:仿宋_GB2312;mso-fareast-font-family:
仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:minor-bidi;
color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:en-US;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">——</span><span style="font-family:仿宋_GB2312;mso-ascii-font-family:仿宋_GB2312;mso-fareast-font-family:
仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:minor-bidi;
color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">生产过程高温或大量使用有机溶剂，操作过程复杂</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:Verdana;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">药物溶出速率提高的主要原因</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:仿宋_GB2312;mso-fareast-font-family:
仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:minor-bidi;
color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">药物高度分散于水溶性载体材料中</span></p>
<p style="margin-top: 0pt; margin-bottom: 0pt; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:黑体;mso-fareast-font-family:
仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:minor-bidi;
color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">常用载体材料</span></p>
<div>水溶性载体材料</div><div><br></div>
<div>难溶性和肠溶性载体材料</div><div><br></div>
<p style="margin-top: 0pt; margin-bottom: 0pt; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:黑体;mso-fareast-font-family:
仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:minor-bidi;
color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">固体分散体的速释原理和类型</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:Verdana;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">速释原理</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:仿宋_GB2312;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">药物的高度分散性</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">分子分散</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">无定形和微晶态分散</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:仿宋_GB2312;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">载体的作用</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">提高药物溶解度</span><span style="font-family:"Times New Roman";mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:en-US;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">——</span><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">对药物的增溶能力与载体材料的浓度呈正相关</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">抑晶作用</span><span style="font-family:"Times New Roman";mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:en-US;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">——</span><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">在固体分散体的制备过程中，药物与载体分子之间由于氢键、络合等作用，使药物晶核的形成和生长受到抑制，药物以无定形状态存在于载体材料中，有利于药物的释放</span></p>
保证药物高度分散性——固体分散体中药物（分子、晶粒等）被载体材料包围，载体材料可防止药物的聚集，保证药物以高度分散的形式存在于载体中
<span style="font-family:仿宋_GB2312;mso-ascii-font-family:
"Times New Roman";mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;
mso-bidi-theme-font:minor-bidi;color:black;mso-color-index:3;mso-font-kerning:
12.0pt;language:zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:
text2;mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">润湿性</span><span style="font-family:"Times New Roman";mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:en-US;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">——</span><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">以水溶性载体材料制备固体分散体时，每一个药物微晶均被载体紧密包围，水溶性材料的溶解可促进药物与水的接触、润湿，轻微搅拌即可形成极细的均匀混悬液，有利于药物的溶出</span>
<div>固体分散体的类型</div><div><br></div>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:仿宋_GB2312;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">分类</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">按药物的溶出行为分类</span></p>
<div>速释型固体分散体</div><div><br></div>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">缓释型</span><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">固体分散体</span></p>
<div>肠溶型固体分散体</div><div><br></div>
<div>按固体分散体的制备原理分类</div><div><br></div>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">低共熔物、固体溶液、共沉淀物、玻璃溶液</span></p>
<div>药物的分散状态</div><div><br></div>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:仿宋_GB2312;mso-fareast-font-family:
仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:minor-bidi;
color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">微晶状态、胶体状态、分子状态、无定形状态（可单独或多种形式共存）</span></p>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:仿宋_GB2312;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">简单低共熔物</span></p>
<span style="font-family:仿宋_GB2312;mso-ascii-font-family:
"Times New Roman";mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;
mso-bidi-theme-font:minor-bidi;color:black;mso-color-index:3;mso-font-kerning:
12.0pt;language:zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:
text2;mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">将低共熔比例的难溶性药物与载体材料共熔后迅速冷却固化，即可得到两者超细结晶的物理混合物，即低共熔物</span>
<p style="margin-top: 4.32pt; margin-bottom: 0pt; margin-left: 0.5in; text-indent: 0in; direction: ltr; unicode-bidi: embed; vertical-align: baseline;"><span style="font-family:仿宋_GB2312;mso-ascii-font-family:仿宋_GB2312;
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">固体溶液</span></p>
<span style="font-family:仿宋_GB2312;mso-ascii-font-family:
"Times New Roman";mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;
mso-bidi-theme-font:minor-bidi;color:black;mso-color-index:3;mso-font-kerning:
12.0pt;language:zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:
text2;mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">固体溶液</span><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">由药物溶解在熔融的载体中冷却固化而成，溶质主要以分子状态分散于固体载体中，形成均相体系，类似于真溶液的分散体系</span>
<div>共沉淀物</div><div><br></div>
<span style="font-family:仿宋_GB2312;mso-ascii-font-family:
"Times New Roman";mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;
mso-bidi-theme-font:minor-bidi;color:black;mso-color-index:3;mso-font-kerning:
12.0pt;language:zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:
text2;mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">共沉淀物</span><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">也称共蒸发物</span><span style="font-family:仿宋_GB2312;mso-ascii-font-family:"Times New Roman";
mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;mso-bidi-theme-font:
minor-bidi;color:black;mso-color-index:3;mso-font-kerning:12.0pt;language:zh-CN;
mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:text2;
mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">，是药物以分子形式不规则地分散在无定形载体材料中形成的一种固体分散体类型</span>
<span style="font-family:仿宋_GB2312;mso-ascii-font-family:
"Times New Roman";mso-fareast-font-family:仿宋_GB2312;mso-bidi-font-family:+mn-cs;
mso-bidi-theme-font:minor-bidi;color:black;mso-color-index:3;mso-font-kerning:
12.0pt;language:zh-CN;mso-style-textfill-type:solid;mso-style-textfill-fill-themecolor:
text2;mso-style-textfill-fill-color:black;mso-style-textfill-fill-alpha:100.0%">固体分散技术</span>
将药物均匀分散于固体载体的技术
姓名：谭畅
学号：2016520461
班级：制药升14级
职业：暂无
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